Asthma susceptibility loci located at chromosome 1q31 for use in diagnostic and therapeutic methods
AssigneeThe Children's Hospital of Philadelphia
InventorsHakon Hakonarson, Patrick M. A. Sleiman
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Abstract
Methods and composition are provided for diagnosing pediatπc onset asthma based on the single nucleotide polymorphism on chromosome 1q31 wherein said single nucleotide polymorphism is set forth in Table 2 or Table 6 of the instant invention Method and composition are also provided for treating and preventing asthma or other inflammatory conditions in a patient in need thereof compπsing administering an effective amount of an at least one inhibitor which reduces the expression of DENND1 B gene product.
Claims3
A solid support having affixed thereon a collection of single nucleotide polymorphism (SNP)-containing isolated nucleic acids wherein each nucleic acid of the collection is at least 15 nucleotides in length, wherein the collection includes each allele of the SNPs, said SNPs being associated with an altered risk of developing pediatric onset asthma and consisting of
- rs2786098, rs2821106, rs12134409, rs2111931, rs10737692, rs12127378, rs12041661, rs10442656, rs2477070, rs1747827, rs2488411, rs1891497, rs1747815, rs1775454, rs1775456, rs1924518, rs1775444, rs12026183, rs10922300, rs10922326, rs2821125, rs1337168, rs1337167, rs2786101, rs2821116, rs2786119rs2786117, rs10801603, rs2821107, rs2759656, rs2821103, rs2759661, rs2476019, rs2821132, rs17554990, rs6685222, rs17555558, rs10922234, rs12023045, rs12563307, rs12133659rs12132165, rs4915550, rs4915551, rs4915552, rs10754224, rs4316386, rs10922251, rs6677361, rs12028758, rs10922253, rs10494758, rs2111931, rs1421397, rs6689216, rs10922255, rs10922256, rs10922257, rs6676073, rs10737692, rs4915555, rs12131160, rs2193734, rs8179369, rs12747786, rs6428411, rs6428412, rs1833464, rs1362939, rs12116508, rs4915557, rs4915558, rs3814321, rs12133885, rs1775453, rs2488409, rs2488410, rs1775450, rs1747811, rs1578720, rs2358774, rs1573098, rs1621898, rs1775457, rs2147300, rs2488387, rs1747815, rs1747814, rs2488400, rs1747817, rs1775441, rs1775442, rs1342696, rs1539413, rs2488394, rs2488395, rs2488396, rs1342694, rs2477069, rs1775469, rs1747825, rs1775468, rs1775467, rs1775466, rs1775465, rs1775464, rs1747823, rs2454640, rs1499593, rs10922288, rs12740849, rs2133536, rs12125742, rs4915566, rs6428417, rs10922294, rs6697696, rs6704186, rs4915569, rs12140293, rs12118454, rs10801625, rs10922304, rs10922305, rs1499602, rs10801629, rs10801632, and rs9662705, wherein said isolated SNP-containing nucleic acids are immobilized on a gene chip or a solid support.
Dependencies are inferred from the claim text.