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US 9,790,539 B2Granted
Methods and reagents for improved selection of biological molecules
AssigneeRussell Biotech, Inc.
InventorsThomas R. Russell, Michael J. Ciocci, Michael Musick
Life of this patent
Estimating the term…
Abstract
Coated Ferromagnetic Density Particles or Density Particles with binding agents bound thereto capable of binding biological molecules and methods of use and apparatus for means are disclosed. Coated particles coupled to specific binding agents can be used for molecular biology and proteomic applications in research and diagnostics.
Claims20
A plurality of coated particles, said particles comprising:
- ferromagnetic metal particles having a diameter of about 0.1 to about 2 microns and a density of about 9 gm/cm3, having a protective layer to prevent ion leaching wherein said protective layer does not alter the settling and magnetic properties of the particles, and wherein said particles remain magnetic after removal of a magnetic field;
- and said particles being coated with a blocking agent and at least one binding agent to have predetermined biological molecules bind thereto, said binding agent selected from the group consisting of an antibody, an antigen, a nucleic acid, a complementary nucleic acid, a lectin, a carbohydrate, avidin, biotin, a protein, a glycoprotein, and a lipid.
Dependencies are inferred from the claim text.