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US 9,790,522 B2Granted
Compositions and methods for the conversion of short-chained carboxylic acids to alcohols using clostridial enzymes
AssigneeSynata Bio, Inc.
InventorsAndrew Reeves, Richard Tobey, Mike Enzien
Life of this patent
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Abstract
The invention relates to the fields of bacterial metabolism and the utilization or consumption of short-chain carboxylic acids to reduced products. Specifically, it relates to syngas fermentations using monocultures of syngas-utilizing homoacetogenic bacteria for the production of alcohols using native alcohol dehydrogenase.
Claims4
A microorganism co-culture for butanol production by the conversion of syngas to butanol comprising:
- (i) a recombinant C1-fixing homoacetogen microorganism grown on a medium containing syngas as the sole carbon source under anaerobic condition wherein said C1-fixing homoacetogen microorganism is capable to convert the syngas to butanol and comprises a heterologous gene encoding an aldehyde ferredoxin oxidoreductase polypeptide modulated by a promoter, (ii) and a C4-producing butyrate microorganism, wherein the nucleotide sequence of aldehyde ferredoxin oxidoreductase gene has greater than 97% sequence identity to SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.