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US 9,790,504 B2Granted
Anti-tumor therapy
AssigneeThe University of Chicago
InventorsNikolai Khodarev, Ravi Sood, Bernard Roizman, Ralph R. Weichselbaum
Life of this patent
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Abstract
Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.
Claims5
A method of treating cancer in a subject by increasing the sensitivity of tumor cells of the subject to radiotherapy comprising:
- a) administering to the tumor cells a siRNA or shRNA that directly targets DHX58 mRNA in an amount that is sufficient to suppress expression of the DHX58 gene thereby increasing the sensitivity of the cells to radiotherapy;
- and
- b) administering to the subject a therapeutically effective amount of radiotherapy.
Dependencies are inferred from the claim text.