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US 9,790,498 B2Granted
Phase changing formulations of nucleic acid payloads
AssigneeDicerna Pharmaceuticals, Inc.
InventorsBob Dale Brown, Sujit Kumar Basu
Life of this patent
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Abstract
The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations.
Claims18
A method for reducing expression of a target gene in a cell of a subject, comprising:
- contacting said cell with a formulation comprising a DsiRNA and a phase changing peptide, wherein said peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs.:
- 1-50, in an amount effective to reduce expression of said target gene in said cell in comparison to a reference dsRNA.
Dependencies are inferred from the claim text.