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US 9,790,496 B2Granted
Microrna compounds and methods for modulating MIR-21 activity
AssigneeRegulus Therapeutics Inc.
InventorBalkrishen Bhat
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Abstract
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.
Claims15
A modified oligonucleotide consisting of 16, 17, or 18 linked nucleosides of the structure:
- (SEQ ID NO:
- 3)
- 5′-AECSATCSAGTCSTGAUSAAGCSTAE-3′
- wherein nucleosides not followed by a subscript are β-D-deoxyribonucleosides;
- nucleosides followed by a subscript “E” are 2′-methoxyethyl (2′-MOE) nucleosides;
- and nucleosides followed by a subscript “S” are S-constrained ethyl (S-cEt) nucleosides;
- and wherein each internucleoside linkage is a phosphorothioate linkage.
4 more elements
Dependencies are inferred from the claim text.