Agent for treating cancer
AssigneesNational Cancer Center, Asahi Kasei Pharma Corporation
InventorsTakahiro Ochiya, Fumitaka Takeshita
Life of this patent
Estimating the term…
Abstract
[Problem] To provide the following: an agent for treating cancer, particularly an agent for inhibiting cancer cell proliferation or an agent for inhibiting or preventing cancer metastasis; drug that uses the agent; a method for assessing the effect of cancer treatment; a method for estimating the prognosis of cancer treatment; a method for screening for a substance having a cancer proliferation-inhibiting effect; and a method for screening a substance having a cancer metastasis-impeding effect. [Solution] Provided is a drug containing a nucleic acid formed from a nucleotide sequence having sequence identity of 70% or greater with at least sequence No. 1 or No. 2, wherein the nucleic acid shows protein expression-inhibiting activity.
Claims25
A method for treating cancer, which comprises administering any of the following (1) to (3) to a mammal:
- (1) a nucleic acid comprising a nucleotide sequence shown by SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- (2) a nucleic acid comprising a nucleotide sequence having 70% or higher sequence identity with SEQ ID NO:
- 1 or SEQ ID NO:
- 2 the nucleic acid presenting protein expression-suppressing activity, and
- (3) a single-stranded or double-stranded nucleic acid containing a nucleotide sequence of (1) or (2) above and a sequence complementary to said nucleotide sequence, thereby forming a double-stranded structure in all or part of the strand.
A method for suppressing or preventing metastasis of cancer, which comprises administering any one of the following (1) to (3) to a mammal:
- (1) a nucleic acid comprising a nucleotide sequence shown by SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- (2) a nucleic acid comprising a nucleotide sequence having 70% or higher sequence identity with SEQ ID NO:
- 1 or SEQ ID NO:
- 2 the nucleic acid presenting protein expression-suppressing activity, and
- (3) a single-stranded or double-stranded nucleic acid containing a nucleotide sequence of (1) or (2) above and a sequence complementary to said nucleotide sequence, thereby forming a double-stranded structure in all or part of the strand.
A method for suppressing or preventing metastasis of bladder cancer comprising administering to a mammal in need thereof a medicine comprising a pharmaceutically acceptable carrier and any one of the following (1) to (3) in an aqueous or nonaqueous sterile formulation for parenteral administration:
- (1) a nucleic acid comprising a nucleotide sequence shown by SEQ ID NO:
- 1 or SEQ ID NO:
- 2:
- (2) a nucleic acid comprising a nucleotide sequence having 70% or higher sequence identity with SEQ ID NO:
- 1 or SEQ ID NO:
- 2 the nucleic acid presenting protein expression-suppressing activity, and
- (3) a single-stranded or double-stranded nucleic acid containing a nucleotide sequence of (1) or (2) above and a sequence complementary to said nucleotide sequence, thereby forming a double-stranded structure in all or part of the strand.
Dependencies are inferred from the claim text.