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US 9,790,468 B2Granted
Multifunctional immature dental pulp stem cells and therapeutic applications
AssigneesAvita Iinternational Ltd., FundaçCãO Butantan
InventorsIrina Kerkis, Sabina Glozman
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Abstract
The present invention is directed to therapeutic multifunctional immature dental pulp stem cells (IDPSCs), and IDPSCs multi-lineage compositions. The invention is further directed to the use of IDPSCs and compositions to reduce the risk of and/or treat degenerative diseases or for other medicinal and aesthetic purposes.
Claims11
A method of treating a disease or condition of ectodermal origin, wherein the disease or condition is selected from the group consisting of:
- a demyelinating disease, wherein the demyelinating disease attacks the central nervous system or the peripheral nervous system, and a spinal cord injury,
- the method comprising systemically administering to a subject in need thereof a composition comprising a population of migratory immature dental pulp stem cells (IDPSCs) expressing CD73 (ecto-5′-nucleotidase), p53, and p75 in an amount sufficient to treat the disease or condition of ectodermal origin.
Dependencies are inferred from the claim text.