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US 9,790,467 B2Granted
Methods and compositions for activation or expansion of T lymphocytes
AssigneeQT Holdings Corp
InventorsSean H. Kevlahan, Andrew Ball, Guokui Qin, Steven B. Wells, Nithya Jothi Jesuraj
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Abstract
The invention features a complex that binds to, stimulates, and expands a desired T cell population and facilitates separation of the target population from a sample. The complex can be gently dissociated from the binding unit after separating the desired T cell population, representing a safe and efficient approach for processing T cells for clinical use. Invention also provides methods of using such complexes as part of adoptive T cell therapy systems.
Claims26
A polymeric moiety comprising:
- a hydrogel of an alginic acid-polyethylene glycol (PEG) copolymer, a signal 1 stimulus configured to induce T cell expansion, and a cation;
- wherein the alginic acid-PEG copolymer changes from a solid matrix into a solution or suspension in response to a sufficient decrease of cationic concentration in the environment of the copolymer.
A polymeric moiety comprising:
- (i) a hydrogel of an alginic acid-PEG copolymer and Ca2+, and (ii) anti-CD3 and anti-CD28;
- wherein the alginic acid-PEG copolymer changes from a solid matrix into a solution or suspension in response to a sufficient decrease of Ca2+ concentration in the environment of the copolymer.
Dependencies are inferred from the claim text.