Back to results
US 9,790,324 B2Granted
Functionalized polymers
AssigneeQuiaPEG AB
InventorMarek Kwiatkowski
Life of this patent
Estimating the term…
Abstract
This document relates to functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such functionalized polymers.
Claims14
A compound comprising a water-soluble, non-peptidic, and non-nucleotidic polymer backbone having at least one terminus covalently bonded to a structure of formula (1):
- or a salt thereof,
- wherein:
- A is the point of covalent bonding to the terminus of the polymer backbone, wherein the polymer backbone is poly(ethylene glycol), wherein said poly(ethylene glycol) has an average molecular weight from about 500 Da to about 100,000 Da;
- E is O;
- K is selected from the group consisting of:
- alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene;
- G is selected from the group consisting of:
- hydrogen, alkoxy, and a hydrophobic separation handle;
- Z1 is O;
- Z2 is O;
- L is selected from the group consisting of:
- a divalent radical of a nucleoside, alkylene, alkyleneoxyalkylene, oligomeric alkyleneoxyalkylene, and unsubstituted and substituted arylene;
- M is a protected group that when deprotected is reactive with a biologically active molecule, a group reactive with a biologically active molecule;
- R is absent or selected from the group consisting of:
- hydrogen, a protecting group, a hydrophobic separation handle, or an activating group;
- R1 is absent or a hydrophobic separation handle;
- wherein when M is a protected group that when deprotected is reactive with a biologically active molecule, then R is a protecting group or a hydrophobic separation handle;
- wherein when M is a group reactive with a biologically active molecule, R is absent, hydrogen, or an activating group;
- and
- wherein only one of R, R1, and G can be a hydrophobic separation handle.
17 more elements
A preparation comprising a compound comprising a water-soluble, non-peptidic, and non-nucleotidic polymer backbone having at least one termini covalently bonded to a structure of formula (1):
- or a salt thereof,
- wherein:
- A is the point of covalent bonding to the terminus of the polymer backbone, wherein the polymer backbone is poly(ethylene glycol), wherein said poly(ethylene glycol) has an average molecular weight from about 500 Da to about 100,000 Da;
- E is O;
- K is selected from the group consisting of:
- alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene;
- G is selected from the group consisting of:
- hydrogen, alkoxy, and a hydrophobic separation handle;
- Z1 is O;
- Z2 is O;
- L is selected from the group consisting of:
- a divalent radical of a nucleoside, alkylene, alkyleneoxyalkylene, oligomeric alkyleneoxyalkylene, and unsubstituted and substituted arylene;
- M is a protected group that when deprotected is reactive with a biologically active molecule, a group reactive with a biologically active molecule;
- R is absent or selected from the group consisting of:
- hydrogen, a protecting group, a hydrophobic separation handle, or an activating group;
- R1 is absent or a hydrophobic separation handle;
- provided that only one of R and R1 is a hydrophobic separation handle or the hydrophobicity of one of R or R1 is higher than the other;
- wherein when M is a protected group that when deprotected is reactive with a biologically active molecule, then R is a protecting group or a hydrophobic separation handle;
- wherein when M is a group reactive with a biologically active molecule, R is absent, hydrogen, or an activating group;
- wherein said preparation comprises at least 50% by weight of said compound;
- and
- wherein only one of R, R1, and G can be a hydrophobic separation handle.
19 more elements
Dependencies are inferred from the claim text.