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US 9,790,305 B2Granted
Site specifically incorporated initiator for growth of polymers from proteins
AssigneeFranklin and Marshall College
InventorsRyan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Abstract
The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.
Claims36
A protein-polymer composition comprising:
- a first protein with a site-specifically incorporated unnatural amino acid having a covalently attached polymer, wherein the unnatural amino acid is represented by formula 2:
- wherein R1 and R2 are independently H, C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- X is F, Cl, Br, I, N3, alkoxyamine, or a thiocarbonyl thio moiety;
- A is O, S, or NR, wherein R is H, C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and n is 0, 1, 2, or 3;
- or a salt thereof.
3 more elements
A method for preparing a protein-polymer composition comprising the steps of:
- providing a first protein containing a site specifically incorporated unnatural amino acid initiator, wherein the unnatural amino acid is represented by formula 2:
- wherein R1 and R2 are independently H, C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- X is F, Cl, Br, I, N3, alkoxyamine, A is O, S, or NR, wherein R is H, C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and n is 0, 1, 2, or 3;
- or a salt thereof, a polymerization catalyst precursor, and an organic solvent to an aqueous solution to form an emulsion;
- providing a first radically polymerizable monomer to the emulsion;
- and
- providing a catalyst precursor reducing agent to the emulsion under conditions suitable to initiate the controlled radical polymerization.
5 more elements
A protein-polymer composition comprising a first protein with a site-specifically incorporated unnatural amino acid having a covalently attached polymer, the unnatural amino acid is represented by formula 1:
- wherein X is —N3, or a salt thereof.
Dependencies are inferred from the claim text.