Amphiphilic polymer
AssigneeKookmin University Industry Academy Cooperation Foundation
InventorsYeon-Gyu Yu, Moon-Hee Sung
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Abstract
The present invention relates to an amphiphilic polymer which includes a large amount of hydrophilic structures and hydrophobic structures, and thereby effectively stabilizing a membrane protein having a hydrophobic surface in an aqueous solution. A method of preparing an amphiphilic polymer represented by Formula 1 includes reacting a poly-gamma-glutamic acid with a reaction product of a fluorescent dye, biotin, an alkyl carboxylic acid having 1 to 10 carbon atoms or a cycloalkyl carboxylic acid having 5 to 20 carbon atoms having a carboxyl group, and dicyclo-hexylcarbodiimide (DCC) and reacting the poly-gamma-glutamic acid with DCC after reacting the poly-gamma-glutamic acid with the reaction product, and reacting the poly-gamma-glutamic acid with a hydrophilic amine and a hydrophobic amine.
Claims8
An amphiphilic polymer represented by the following Formula 1:
- where R1 is a fluorescent dye, a biotin group, an alkyl group having 1 to 10 carbon atoms, or a cycloalkyl carbonyl group having 5 to 20 carbon atoms;
- R2, R3, R4 and R5 have a structure independently derived from a hydroxy group, or a hydrophilic or hydrophobic amine,
- repeated units of R3 have identical or different structures, one or more of the repeated units of R3 have a structure derived from a hydrophilic amine, one or more of the repeated units of R3 have a structure derived from a hydrophobic amine;
- and n is an integer in a range of 1 to 1,000,
- wherein the hydrophilic amine is an alkyl amine having 1 to 10 carbon atoms or a cycloalkyl amine having 5 to 20 carbon atoms, which is substituted with a hydroxy group or an amino group;
- and
- the hydrophobic amine is an alkyl amine having 1 to 10 carbon atoms or a cycloalkyl amine having 5 to 20 carbon atoms.
Dependencies are inferred from the claim text.