Anti-CD38 antibodies
AssigneeTakeda Pharmaceutical Company Limited
InventorsKathleen Ann Elias, Gregory Landes, Shweta Singh, Wouter Korver, Andrew Walling Drake, Mary Haak-Frendscho, Gyorgy Pal Snell, Vinay Bhaskar
Life of this patent
Estimating the term…
Abstract
Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.
Claims24
An isolated nucleic acid encoding the heavy chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the heavy chain variable region comprises SEQ ID NO:9.
An isolated nucleic acid encoding the light chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the light chain variable region comprises SEQ ID NO:10.
An isolated nucleic acid composition comprising:
- i) a first nucleic acid encoding a heavy chain variable region comprising:
- i) a first CDR comprising SEQ ID NO:3;
- ii) a second CDR comprising SEQ ID NO:4;
- iii) a third CDR comprising SEQ ID NO:5;
- and
- ii) a second nucleic acid encoding a light chain variable region comprising:
- i) a first CDR comprising SEQ ID NO:6;
- ii) a second CDR comprising SEQ ID NO:7;
- iii) a third CDR comprising SEQ ID NO:8.
An isolated nucleic acid encoding the heavy chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the heavy chain variable region comprises:
- i) a first CDR comprising SEQ ID NO:13;
- ii) a second CDR comprising SEQ ID NO:14;
- iii) a third CDR comprising SEQ ID NO:15.
An isolated nucleic acid encoding the light chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the light chain variable region comprises:
- i) a first CDR comprising SEQ ID NO:16;
- ii) a second CDR comprising SEQ ID NO:17;
- iii) a third CDR comprising SEQ ID NO:18.
An isolated nucleic acid composition comprising:
- i) a first nucleic acid encoding a heavy chain variable region comprising:
- i) a first CDR comprising SEQ ID NO:13;
- ii) a second CDR comprising SEQ ID NO:14;
- iii) a third CDR comprising SEQ ID NO:15;
- and
- ii) a second nucleic acid encoding a light chain variable region comprising:
- i) a first CDR comprising SEQ ID NO:16;
- ii) a second CDR comprising SEQ ID NO:17;
- iii) a third CDR comprising SEQ ID NO:18.
Dependencies are inferred from the claim text.