Methods for increasing thermogenic adipocytes
AssigneeAcceleron Pharma Inc.
InventorsJohn Knopf, Jasbir Seehra, Ravindra Kumar
Life of this patent
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Noda1, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
Claims18
A method for increasing thermogenic adipocytes in a patient in need thereof, wherein the patient is an adult having an age-related metabolic condition;
- wherein the age-related metabolic condition is selected from the group consisting of:
- sarcopenia, metabolic syndrome, diabetes, arteriosclerosis, and dyslipidemia;
- and wherein the patient has a deficiency in brown adipose tissue or brown adipocytes as compared to the levels of brown adipose tissue or brown adipocytes present in one or more healthy control patients;
- the method comprising administering an effective amount of an antibody, or antigen-binding fragment thereof, selected from the group consisting of:
- an antibody, or antigen-binding fragment thereof, that specifically binds to and inhibits Growth and Differentiation Factor-3 (GDF3);
- an antibody, or antigen-binding fragment thereof, that specifically binds to and inhibits myostatin;
- an antibody, or antigen-binding fragment thereof, that specifically binds to and inhibits Growth and Differentiation Factor-11 (GDF11);
- an antibody, or antigen-binding fragment thereof, that specifically binds to and inhibits nodal;
- and an antibody, or antigen-binding fragment thereof, that specifically binds to and inhibits activin.
Dependencies are inferred from the claim text.