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US 9,790,280 B2Granted
Monoclonal canine CD20 antibodies and methods of use
AssigneeElanco Tiergesundheit AG
InventorsSarah Rue, Brendan Eckelman, Quinn Deveraux, Marc Nasoff
Life of this patent
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Abstract
This disclosure relates to immunogens and monoclonal antibodies useful in the identification and/or treatment of cancer cells, including those of the dog. In one example, chimeric anti-canine CD20 antibodies are provided. The antibodies can be used therapeutically to treat lymphoma in dogs.
Claims7
An isolated monoclonal antibody that binds canine CD20, the antibody comprising at least one set of variable region amino acid sequences selected from the group consisting of:
- a light chain variable region (LC-V) comprising the sequence of
- (SEQ ID NO.:
- 3)
- DVVMTQNPLSLPVSLGDQASISCRSSQSLIYNNGNTYLHWYRQKPGQSPK
- LLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVP
- FTFGSGTKLEIK
- and a heavy chain variable region (HC-V) comprising the sequence of
- (SEQ ID NO.:
- 6)
- EVQLVESGGGLVKPGGSLKLSCAASGFTFSDYGMLWVRQAPEKGLEWIAY
- ISSGSSTIYYADRVKGRFTISRDNAKNTLFLQMTSLRSEDTAMYYCSTGT
- FAYWGQGTPVTVSS;
- an LC-V comprising the sequence of
- (SEQ ID NO.:
- 9)
- DIVMTQAAPSVPVTPGESVSISCRSNKSLLHRNGNTYLYWFLQRPGQSPQ
- LLIYRMSNLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEFP
- FTFGGGTKLEIK
- and a HC-V comprising the sequence of
- (SEQ ID NO.:
- 11)
- EVQLQQSGPELVKPGASVKISCKASGYTFTDYYMNWVKQSHGKSLEWIGD
- INPNNGDTSYNQKFKGKAPLTVDKSSSTAYMEVRSLTSEDSAVYFCARGG
- VLRYPYYYVMDYWGQGTSVTVSS;
- and an LC-V comprising the sequence of
- (SEQ ID NO.:
- 13)
- DIVMTQSQKFMSRSVGDRVSVTCKASQNVGPNVAWYQQRPGQSPKPLIY
- SASYRYSGVPDRFTGSGSGTDFTLTISNVQSEDLAEYFCQQYNNYPYTF
- GGGTKLEIK
- and a HC-V comprising the sequence of
- (SEQ ID NO.:
- 15)
- EVQLQQSGAELVRPGASVKLSCTASGFNIKDDYMHWVKQRPEQGLEWIG
- WIDPENGHTKYASKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCTS
- LRHYYGSSYVSPHYYWGQGTTLTVSS;
- wherein the antibody binds canine CD20.
34 more elements
Dependencies are inferred from the claim text.