US 9,790,279 B2Granted

Pharmaceutical compositions for the treatment of tumors expressing EGFR and GM3 N-glycolyl ganglioside (NeuGcGM3)

AssigneeCentro De Immunologia Molecular

InventorsAdys González Palomo, Adriana Carr Perez, Kalet León Monzón, Rancés Blanco Santana, María del Carmen Barroso Alvarez, Amparo Emilia Macías Abraham, José Enrique Montero Casimiro

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Abstract

The present invention relates to pharmaceutical compositions for the treatment of malignant tumors. Particularly those tumors that express EGFR and GM3 N-glycolyl ganglioside targets to enhance the therapeutic effect produced by separated therapies against these targets. The pharmaceutical compositions of the invention include antibodies and/or vaccines against each of the targets. Additionally the present invention relates to methods for applying the compositions of the invention.

Claims18

Dependent claims

A method for retarding tumor growth of a tumor that co-expresses EGFR and N-glycolyl GM3 (NeuGcGM3) ganglioside targets in a patient in need thereof, comprising:

(a) administering to a patient a medicament comprising a monoclonal antibody (MAb) directed against EGFR and,
(b) administering to the same patient a medicament comprising a vaccine against NeuGcGM3 ganglioside.

Dependencies are inferred from the claim text.

Facts

Application: 14/369,435Filed 4 Dec 2012
Priority: CU 2011/024527 Dec 2011
Published: US 2014/0363494 A111 Dec 2014
Granted: 17 Oct 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07K 16/2863
Against receptors, cell surface antigens or cell surface determinants: against receptors for growth factors, growth regulators
A61K 39/001104
Receptors for growth factors: epidermal growth factor receptors [EGFR]
A61K 39/001171
Tumor associated carbohydrates: gangliosides, e.g. GM2, GD2 or GD3
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines