Anti-H7CR antibodies
AssigneesThe Johns Hopkins University, MedImmune, LLC
InventorsSolomon Langermann, Linda Liu, Sheng Yao, Lieping Chen
Life of this patent
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Abstract
Antibodies and humanized variants thereof and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H7 counter-receptor, H7CR, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.
Claims34
A humanized antibody or an antigen-binding fragment thereof that specifically binds to human H7CR, comprising:
- (A) (1) a light chain variable region having the amino acid sequence of any of SEQ ID NOS:
- 17-22;
- and
- (2) a heavy chain variable region having the amino acid sequence of any of SEQ ID NOS:
- 23-28;
- or
- (B) (1) a light chain variable region having the amino acid sequence of any of SEQ ID NOS:
- 33-38;
- and
- (2) a heavy chain variable region having the amino acid sequence of any of SEQ ID NOS:
- 39-44.
An antigen-binding antibody fragment of a humanized anti-H7CR antibody that specifically binds to human H7CR as antigen, wherein the antigen-binding fragment comprises six CDRs, which comprise:
- (A) three light chain CDRs having SEQ ID NOS:
- 29, 32, 45 and three heavy chain CDRs having SEQ ID NOS:
- 49, 52, and 56;
- (B) three light chain CDRs having SEQ ID NOS:
- 30, 32, 46 and three heavy chain CDRs having SEQ ID NOS:
- 50, 53, and 57;
- or
- (C) three light chain CDRs having SEQ ID NOS:
- 29, 32, 47 and three heavy chain CDRs having SEQ ID NOS:
- 50, 54, and 58.
An antigen-binding fragment of an anti-H7CR antibody that specifically binds to human H7CR, wherein said antigen-binding fragment comprises:
- (A) (1) a light chain variable region having the amino acid sequence of SEQ ID NO:
- 5;
- and
- (2) a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 6;
- (B) (1) a light chain variable region having the amino acid sequence of SEQ ID NO:
- 7;
- and
- (2) a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 8;
- or
- (C) (1) a light chain variable region having the amino acid sequence of SEQ ID NO:
- 9;
- and
- (2) a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 10.
A humanized antibody or an antigen-binding fragment thereof that specifically binds to human H7CR, comprising:
- (1) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 23;
- (2) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 24;
- (3) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 25;
- (4) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 26;
- (5) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 27;
- (6) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 17 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 28;
- (7) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 18 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 24;
- (8) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 18 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 25;
- (9) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 18 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 27;
- (10) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 18 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 28;
- (11) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 19 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 24;
- (12) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 19 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 25;
- (13) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 19 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 27;
- or
- (14) a light chain variable region comprising amino acid sequence SEQ ID NO:
- 19 and a heavy chain variable region comprising amino acid sequence SEQ ID NO:
- 28.
A humanized antibody or an antigen binding fragment of an antibody that specifically binds a human H7CR, wherein the antibody or the antigen-binding fragment comprises a light chain variable region that comprises a light chain CDR1 of SEQ ID NO:
- 29, a light chain CDR2 of SEQ ID NO:
- 32 and a light chain CDR3 of SEQ ID NO:
- 45;
- and a heavy chain variable region that comprises a heavy chain CDR1 of SEQ ID NO:
- 49;
- a heavy chain CDR2 of SEQ ID NO:
- 52 and a heavy chain CDR3 of SEQ ID NO:
- 56.
A humanized antibody or an antigen binding fragment thereof that specifically binds to human H7CR, wherein said antibody or an antigen-binding fragment thereof comprises a light chain variable region comprising a light chain CDR1 of SEQ ID NO:
- 31, a light chain CDR2 of SEQ ID NO:
- 32, and a light chain CDR3 of SEQ ID NO:
- 48 and a heavy chain variable region comprising a heavy chain CDR1 of SEQ ID NO:
- 51, a heavy chain CDR2 of SEQ ID NO:
- 55 and a heavy chain CDR3 of SEQ ID NO:
- 59.
Dependencies are inferred from the claim text.