Compositions and methods to enhance the immune system
AssigneeStichting Sanquin Bloedvoorziening
InventorTimo Kars Van Den Berg
Life of this patent
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Abstract
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g. cancer cells or virus-infected cells, by the host's immune system. Provided is a composition comprising (i) a therapeutic compound that can trigger a host's immune effector cells against an aberrant cell, such as a therapeutic antibody, and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPalpha.
Claims29
A method of enhancing in vivo efficacy of a therapeutic antibody to induce cancer cell destruction by antibody-dependent cellular cytotoxicity (ADCC) in a human subject receiving anti-cancer treatment with a therapeutic antibody comprising a human or non-human primate IgG Fc portion, wherein the therapeutic antibody induces ADCC, said method comprising administering to said subject prior to, simultaneously, or after the administration of the therapeutic antibody, an agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPα, wherein the agent is in an amount sufficient to increase ADCC such that the in vivo efficacy of the therapeutic antibody to induce cancer cell destruction by ADCC is enhanced, and wherein said agent is an anti-SIRPα antibody or a Fab fragment thereof, a F(ab′)2 fragment thereof, or a ScFv fragment thereof.
A method of treating cancer in a subject receiving anti-cancer treatment with a therapeutic antibody selected from the group consisting of rituximab, trastuzumab, alemtuzumab, bevacizumab, cetuximab, and panitumumab, said method comprising administering to said human subject prior to, simultaneously, or after the administration of the therapeutic antibody, an anti-SIRPα antibody, a Fab fragment thereof, a F(ab′)2 fragment thereof, or a ScFv fragment thereof.
Dependencies are inferred from the claim text.