Methods for increasing immunoglobulin A levels
AssigneeVaccinex, Inc.
InventorsMaurice Zauderer, Masaru Yoshida, Koji Yamamoto, Ernest S. Smith
Life of this patent
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Abstract
Methods for increasing immunoglobulin A (IgA) levels in a subject having a deficiency thereof are provided herein by administering to the subject an agent that inhibits CXCL13 activity, such as an anti-CXCL13 or an anti-CXCR5 antibody. Further provided are methods for treating an inflammatory disorder in a subject deficient for IgA by administering to the subject an agent that inhibits CXCL13 activity.
Claims30
A method for increasing immunoglobulin A (IgA) levels in a subject having a deficiency thereof, said method comprising administering to said subject an effective amount of an antibody or antigen-binding fragment thereof that specifically binds CXCL13 and inhibits CXCL13 activity, wherein the antibody or antigen-binding fragment thereof
- a) comprises a variable heavy (VH) domain having three complementarity determining regions (CDRs) of SEQ ID NO:
- 10 and a variable light (VL) domain having three CDRs of SEQ ID NO:
- 15;
- b) comprises a variable heavy (VH) domain having three complementarity determining regions (CDRs) of SEQ ID NO:
- 14 and a variable light (VL) domain having three CDRs of SEQ ID NO:
- 19;
- or
- c) comprises a variable heavy (VH) domain having three complementarity determining regions (CDRs) of SEQ ID NO:
- 14 and a variable light (VL) domain having three CDRs of SEQ ID NO:
- 21.
Dependencies are inferred from the claim text.