Compounds and methods for modulating pharmacokinetics
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsRichard T. Lee, Parth Patwari, James Pancoast
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Abstract
Methods and compositions are described for management of the pharmacokinetic properties of active agents, e.g., therapeutic moieties, by conjugating, fusing, or non-direct linkage of the active agent to one or more wild-type or modified heparin-binding peptides (HB). Compounds may be administered to tissues including skin. Contemplated uses include treatment of disease, allergen immunotherapy, and immunization. Other aspects relate to compositions, methods and kits comprising heparin-binding peptides (HB) fused or conjugated to the therapeutic agents.
Claims10
A composition for controlled systemic release of a therapeutic, the composition comprising:
- a therapeutic moiety;
- and
- at least one heparin binding peptide linked to the therapeutic moiety, wherein the heparin binding peptide includes a portion with a sequence selected from the group consisting of KRKKKGKGLGKKRDPRLRKYK (SEQ ID NO:
- 2);
- and KRKKKGKGLGKKRDPKLRKYK (SEQ ID NO:
- 3).
A composition for increasing retention of a therapeutic in tissue, the composition comprising:
- a therapeutic protein;
- and
- at least one heparin binding peptide linked to the therapeutic protein, wherein the heparin binding peptide includes a portion with a sequence selected from the group consisting of KRKKKGKGLGKKRDPRLRKYK (SEQ ID NO:
- 2);
- and KRKKKGKGLGKKRDPKLRKYK (SEQ ID NO:
- 3).
Dependencies are inferred from the claim text.