Self-assembled peptide nanostructures
AssigneeRamot at Tel-Aviv University Ltd.
InventorsPini Marco, Lihi Adler-Abramovich, Ehud Gazit
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Abstract
Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.
Claims17
A composition comprising a plurality of tubular nanostructures, wherein at least 80% of said nanostructures are characterized by a length smaller than 10 microns, each of said nanostructures being formed of a plurality of aromatic dipeptides, said plurality of aromatic dipeptides comprising at least two different types of aromatic dipeptides, at least one type of said aromatic dipeptides being an end-capping modified aromatic dipeptide and at least one type of aromatic dipeptides being a non-modified aromatic dipeptide,
- wherein each of said non-modified aromatic dipeptides is a phenylalanine-phenylalanine dipeptide and each of said end-capping modified dipeptides is an N-terminus modified peptide, said end capping moiety being tert-butoxycarbonyl (Boc),
- wherein a molar ratio of said at least two types of aromatic dipeptides in said plurality of aromatic dipeptides is such that provides tubular nanostructures characterized by said length.
A composition comprising a plurality of tubular nanostructures, each of said nanostructures being formed of a plurality of aromatic dipeptides, said plurality of aromatic dipeptides comprising at least two different types of aromatic dipeptides co-assembled with one another, at least one type of said aromatic dipeptides being an end-capping modified aromatic dipeptide and at least one type of aromatic dipeptides being a non-modified aromatic dipeptide,
- wherein each of said non-modified aromatic dipeptides is a phenylalanine-phenylalanine dipeptide and each of said end-capping modified dipeptides is an N-terminus modified peptide, said end capping moiety being tert-butoxycarbonyl (Boc),
- wherein a length distribution of said nanostructures has a full-width-at-half-maximum (FWHM) of less than 10 microns.
Dependencies are inferred from the claim text.