Back to results
US 9,790,235 B2Granted
MK2 inhibitors and uses thereof
AssigneeCelgene CAR LLC
InventorsMatthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds, compositions thereof, and methods of using the same.
Claims18
A compound of formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- T is —NH— or —O—;
- each R is independently hydrogen or an optionally substituted C1-6 aliphatic, or:
- two R groups on the same nitrogen are taken together with the nitrogen to form a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur;
- R1 is methyl;
- R2 is halogen, —CN, —SRy, —S(O)Ry, —SO2Ry, —OSO2Ry, —OC(O)Ry, or —OP(O)2ORy;
- each Ry is independently selected from optionally substituted C1-6 aliphatic or optionally substituted phenyl;
- R3 is hydrogen, optionally substituted C1-6 aliphatic, —CN, —NO2, halogen, —OR, —N(R)2, —C(O)N(R)2, —C(O)OR, -Cy, —C(O)N(R)-Cy, —C(O)-Cy, —O-Cy, —O—(CH2)n-Cy, —(CH2)n—O-Cy, —N(R)-Cy, —N(R)—(CH2)n-Cy, —(CH2)n—N(R)-Cy, or —(CH2)m-Cy;
- each of m and n is independently 0-4;
- and
- each Cy is independently an optionally substituted ring selected from a 3-9 membered saturated or partially unsaturated monocyclic carbocyclic ring, a 3-9 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, phenyl, a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 7-12 membered saturated or partially unsaturated fused or bridged bicyclic carbocyclic ring, or a 7-12 membered saturated or partially unsaturated fused or bridged bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur.
8 more elements
Dependencies are inferred from the claim text.