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US 9,790,230 B2Granted
2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
AssigneeHoffmann-La Roche Inc.
InventorsGiuseppe Cecere, Guido Galley, Yimin Hu, Roger Norcross, Philippe Pflieger, Hong Shen
Life of this patent
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Abstract
The present invention relates to compounds of formula of formula I wherein X, L and R1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula I.
Claims10
A compound of formula I
- wherein
- L is a bond, —C(O)NH—, —NHC(O)—, —CH2NHC(O)—, CH2C(O)NH—, —CH2NH—, —NH— or —NHC(O)NH—;
- R1 is hydrogen, lower alkyl, halogen, lower alkoxy-alkyl, lower alkoxy substituted by halogen, lower alkyl substituted by halogen, phenyl or heteroaryl wherein said heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl and pyrazolyl, and wherein said phenyl or said heteroaryl are optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl and O—CH2-cycloalkyl;
- X is CH or N;
- or a pharmaceutically suitable acid addition salt thereof and an enantiomer, a racemic mixture or a mixture of enantiomers.
2 more elements
Dependencies are inferred from the claim text.