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US 9,790,218 B2Granted
Small molecule activators of calcium-activated chloride channels and methods of use
AssigneeThe Regents of the University of California
InventorsAlan S. Verkman, Wan Namkung
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Abstract
Provided herein are small molecule activators of calcium-activated chloride channels. These small molecules may be used for treatment of diseases and disorders that are treatable by activating calcium-activated chloride channels, such as cystic fibrosis, disorders related to salivary gland dysfunction (for example, Sjogren's syndrome and dysfunction following radiation injury), dry eye syndrome, and intestinal hypomotility.
Claims8
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of structure (I):
- or a stereoisomer, tautomer, solvate, or pharmaceutically acceptable salt thereof, wherein
- R1, R2 and R3 are each independently alkoxy;
- R4 is heteroaralkyl, or heterocyclylalkyl;
- and
- R5 and R6 are each independently hydrogen, alkoxy or halo,
- wherein the pharmaceutical composition is inhalable and the pharmaceutically acceptable excipient is not dimethyl sulfoxide (DMSO).
3 more elements
Dependencies are inferred from the claim text.