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US 9,790,217 B2Granted
Pyridinyloxy- and phenyloxy-pyrazolyl compounds
AssigneeHoffmann-La Roche Inc.
InventorsJohannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Dongbo Li, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Jun Wu
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Abstract
The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
Claims20
A compound of formula (I) wherein
- R1 is substituted phenyl or substituted pyridinyl, wherein substituted phenyl and substituted pyridinyl are substituted with one to three substituents independently selected from cyano, halogen, haloalkyl, alkoxy and alkyl;
- R2 is a ring system selected from group A, B, C, D, E, F, G and H:
- R3 and R7 are independently selected from H, alkyl, alkoxy, halogen, haloalkoxy, carboxy, alkoxycarbonyl, optionally substituted phenylalkoxy, optionally substituted heteroarylalkoxy, optionally substituted heteroarylalkyl, optionally substituted heteroaryloxyalkyl or optionally substituted heterocycloalkoxy, wherein the optionally substituted moieties are substituted with one to three substituents independently selected from alkyl or halogen;
- R4 is (i) H, (ii) hydroxy, (iii) hydroxyalkyl, (iv) alkoxy, (v) alkoxycarbonyl, (vi) halogen, (vii) phenylalkoxy, (viii) heterocycloalkylcarbonyl optionally substituted by one to three substituents independently selected from alkylcarbonyl, alkylsulfonyl or hydroxyalkyl, (ix) heteroarylalkoxy optionally substituted by one to three substituents independently selected from alkyl and halogen, (x) heteroaryloxyalkyl optionally substituted by one to three halogen(s), (xi) heteroarylalkyl optionally substituted by one to three substituents hydroxy, (xii) heterocycloalkoxy optionally substituted by one to three alkylcarbonyl, or (xiii) heterocycloalkylalkyl optionally substituted by one to three substituents independently selected from halogen and hydroxyalkyl;
- R6 is H or halogen;
- R5 is H, halogen, alkoxy, alkylsulfonyl, alkylsulfanyl or haloalkyl;
- R8 is alkyl or phenylalkyl;
- R9 is H, alkylcarbonyl or heteroarylcarbonyl optionally substituted by one to three alkyl groups;
- n is zero, 1 or 2;
- or
- a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.