3-substituted cyclopentylamine derivatives

Compounds of the formula I

• in which
• R denotes Het, or —C≡C-Het,
• W denotes furanyl, thiophenyl, pyrrolyl, pyrazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl or thiadiazolyl, each of which is unsubstituted or mono- or disubstituted by R2,
• Rl denotes A, [C(R3)2]nAr1 or [C(R3)2]nCyc,
• R2 denotes A, [C(R3)2]nAr1, Cyc or═O
• R4 denotes H, F, Cl, Br, OH, CN, NO2, A′, OA′, SA′, SO2Me, COA′, CONH2, CONHA′ or CONA′2,
• X1, X2, X3, X4 each, independently of one another, denote CH or N,
• A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein two adjacent carbon atoms may form a double bond and/or one or two non-adjacent CH- and/or CH2-groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by R5,
• Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by OH, Hal or A,
• A′ denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F,
• R5 denotes F, Cl or OH,
• Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, O[C(R3)2]nHet1, Ar1, [C(R3)2]p OR3, [C(R3)2]pN(R3)2, NO2, CN, [C(R3)2]pCOOR3, CON(R3)2, [C(R3)2]pN(R3)2, N(R3)2COA, NR3SO2A, [C(R3)2]pSO2N(R3)2, S(O)nA, O[C(R3)2]mN(R3)2, NHCOOA, NHCON(R3) 2 and/or COA,
• Ar1 denotes phenyl or naphthyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R3)2]p OR3, [C(R3)2]pN(R3)2, NO2, CN, [C(R3)2]pCOOR3, [C(R3)2]pN(R3)2, N(R3)2COA, NR3SO2A, [C(R3)2]SO2N(R3) 2, S(O)nA, O [C(R3)2]mN(R3)2, NHCOOA, NHCON(R3)2 and/or COA,
• R3 denotes H or unbranched or branched alkyl with 1-6 C-atoms,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R3)2]nOA′, [C(R3)2]nN(R3)2, SR3, NO2, CN, COOR3, CON(R3)2, COHet1, NR3COA, NR3SO2A, SO2N(R3)2, S(O)nA, O [C(R3)2],mN(R3)2, NHCOOA, NHCON(R3)2, CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen),
• Hal denotes F, Cl, Br or I,
• m denotes 1, 2 or 3,
• n denotes 0, 1 or 2,
• p denotes 0, 1, 2, 3 or 4,
• q 0, 1, 2 or 3,
• with the proviso that only one or two of X1, X2, X3, X4 denote N, and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.