Heteroatom containing deoxyuridine triphosphatase inhibitors

A compound, or a tautomer thereof, including any stereoisomer, stereochemically pure enantiomer or diastereoisomer, or a pharmaceutically acceptable salt and/or a solvate of each thereof of formula (III):

• wherein A is
• each V is independently O or S,
• R11 is hydrogen, halo, R12 or —O—R12, wherein R12 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl optionally substituted with 1-3 hydroxy, fluoro, chloro, and amino substituent,
• r is 1, 2, or 3,
• Y10 is O, S, SO, SO2, NH or NR15,or L1 is joined at Y10 with Y10 being a nitrogen atom;
• R15 is C1-C6 alkyl optionally substituted with 1-3 C1-C6 alkoxy, hydroxy, amino, and oxo groups,
• L1- is
• Y1 is CH2, O, S,
• X10 is NH, NCO2R20, O, —CO—, —CO—NH—, or CH2,
• R20 C1-C6 alkyl optionally substituted with 1-3 C6-C10 aryl groups,
• u is 0, 1, 2, 3, or 4,
• Rz is hydroxy or hydrogen,
• RW is C1-C6 alkyl or hydrogen, and
• the phenylene and the heteroarylene rings are optionally substituted,
• Z is phenyl or a 5 or 6 member heteroaryl substituted with an R6 and an R60 groups, wherein the R6 and the R60 are positioned 1,2 with respect to each other,
• R6 is hydrogen, optionally substituted C1-C6 alkoxy, or halo, and
• R60 is —OR7 or —NHR7R70,
• R7 is optionally substituted C1-C10 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C3-C10 heteroaryl, optionally substituted C3-C10 heterocyclyl, or optionally substituted phenyl, and
• R70 is hydrogen or R7.