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US 9,790,211 B2Granted
5-amino-quinoline-8-carboxamide derivatives as 5-HT4 receptor agonists
AssigneeSuven Life Sciences Limited
InventorsRamakrishna Nirogi, Anil Karbhari Shinde, Venkateswarlu Jasti
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Abstract
The present invention relates to novel quinoline compounds of formula (I), and their pharmaceutically acceptable salts and process for their preparation. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptor agonists.
Claims20
A compound of the general formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen;
- “” is a bond represents racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- is
- R1 is hydrogen, hydroxy or fluoro;
- R2 is hydrogen, hydroxy or fluoro;
- R3 is
- R5 is fluoro, hydroxy or methoxy;
- m is 0 or 1 , both inclusive.
7 more elements
A compound selected from:
- (a) a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen;
- “” is a bond represents a racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- is
- R1 is hydrogen, hydroxy or fluoro;
- “m” is 0 or 1, both inclusive;
- R2 is hydroxy or fluoro;
- R3 is
- and
- R5 is fluoro, hydroxy or methoxy;
- (b) a compound of formula (Ib-1):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen;
- “” is a bond which represents a racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- R1 is hydrogen, hydroxy or fluoro;
- “m” is 0 or 1, both inclusive;
- and
- “-------” represents a bond or no bond;
- (c) a compound of formula (Ib-2):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen;
- “” is a bond which represents a racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- R1 is hydrogen, hydroxy or fluoro;
- “m” is 0 or 1, both inclusive;
- and
- “-------” represents a bond or no bond;
- (d) compound of formula (Id-1):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen:
- “” is a bond which represents a racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- R1 is hydrogen, hydroxy or fluoro;
- “m” is 0 or 1, both inclusive;
- and
- “-------” represents a bond or no bond;
- (e) a compound of formula (Id-2):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- “X” is halogen;
- “” is a bond which represents a racemic mixture, R-enantiomer, S-enantiomer, exo isomer, endo isomer or achiral;
- R1 is hydrogen, hydroxy or fluoro;
- “m” is 0 or 1, both inclusive;
- and
- “-------” represents a bond or no bond.
45 more elements
Dependencies are inferred from the claim text.