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US 9,790,200 B2Granted
Dihydroquinoline pyrazolyl compounds
AssigneeHoffmann-La Roche Inc.
InventorsJohannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan
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Abstract
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R15, R16, R17 and n are as described herein, compositions including the compounds and methods of using the compounds.
Claims19
A compound of formula (I)
- wherein
- R1, R5, R6, R7 and R8 are independently selected from H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;
- R2, R3 and R4 are independently selected from H, halogen, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;
- R9 is alkylsulfanylalkyl, alkylsulfonylalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, hetroarylalkyl, substituted heteroarylalkyl or the group A, wherein substituted aryl, substituted arylalkyl, substituted heteroaryl and substituted heteroarylalkyl are substituted with one to three substituents selected from the group consisting of alkyl, halogen, haloalkyl, cycloalkyl, halocycloalkyl, cyano, alkoxy, haloalkoxy, alkylsulfanyl, haloalkylsulfanyl, alkylsulfonyl and haloalkylsulfonyl;
- R10 is pyrazolyl, substituted pyrazolyl, pyridinyl or substituted pyridinyl, wherein substituted pyrazolyl and substituted pyridinyl are substituted with one to three substituents selected from the group consisting of alkyl, halogen, haloalkyl, cycloalkyl and halocycloalkyl;
- R15 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;
- R16 and R17 are independently selected from H, alkyl and cycloalkyl;
- n is zero or 1;
- or, pharmaceutically acceptable salts thereof.
6 more elements
Dependencies are inferred from the claim text.