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US 9,790,199 B1Granted
Sulfoxide compound and method of producing benzothiophene derivatives using the same
AssigneeNational Sun Yat-Sen University
InventorsMing-Jung Wu, Shih-Ming Wen
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Abstract
A sulfoxide compound and method of producing benzothiophene derivatives using the same are provided. The sulfoxide compound is represented by formula (I), wherein R1 and R2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain; and X is halogen atom. The sulfoxide compound reacts with alkynyl compound, and then the synthesis efficiency of benzothiophene derivatives can be effectively increased.
Claims7
A method of producing benzothiophene derivatives, comprising:
- performing a reaction between a sulfoxide compound of formula (I) and an alkynyl compound of formula (II) to produce the benzothiophene derivatives of formula (III):
- wherein R1 and R2 are individually and independently benzoyl group;
- alkyl, acyl or silyl group of C1-C6 straight chain or branched chain;
- or alkenyl group of C3-C6 straight chain or branched chain;
- and X is halogen atom;
- wherein in the formula (II), A is hydrogen atom or silyl group, and R4 is benzoyl group;
- alkyl, acyl or silyl group of C1-C6 straight chain or branched chain;
- or alkenyl group of C3-C6 straight chain or branched chain;
- and
- wherein in the formula (III), R1 and R2 are individually and independently hydrogen atom, benzoyl group;
- alkyl, acyl, or silyl group of C1-C6 straight chain or branched chain;
- or alkenyl group of C3-C6 straight chain or branched chain, and R3 is hydrogen atom or (1-piperidinyl)-(C1-C4)alkyl group.
9 more elements
Dependencies are inferred from the claim text.