KDM1A inhibitors for the treatment of disease

A compound of Formula I:

• or a salt thereof, wherein:
• Y is chosen from a bond, NR4a, O, C(O)NH, NHC(O), S, SO2, and CH2;
• Z is chosen from a bond, NR4b, O, C(O)NH, NHC(O), S, SO2, and CH2;
• m is an integer from 0 to 5;
• n is an integer from 0 to 3;
• R1 and R2 are each independently chosen from, alkyl, aminoalkyl, alkylsulfonylalkyl, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, phenyl, biphenyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl and R1 and R2, together with the nitrogen to which they attach, form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with between 0 and 3 R6 groups;
• or R1 and R2, together with the nitrogen to which they attach, form
• R3 is chosen from alkylamino, cycloalkylamino, arylamino, heteroarylamino, heterocycloalkylamino, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl any of which may be optionally substituted with between 0 and 3 R6 groups;
• R4, R4a, and R4b are independently chosen from hydrogen, alkyl, alkenyl, alkynyl, and cycloalkyl;
• R5 is chosen from aryl and heteroaryl, any of which may be optionally substituted with between 0 and 3 R6 groups;
• each R6 is independently chosen from hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkoxy, aryl, aralkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, cyano, alkoxy, amino, alkylamino, dialkylamino, COR7, SO2R7, NHSO2R7, NHSO2NHR7, NHCOR7, NHCONHR7, CONHR7, and CONR7R8;
• and
• R7 and R8 are independently chosen from hydrogen, and lower alkyl;
• or R7 and R8 may be taken together to form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with lower alkyl.