Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group

A compound of formula (I)

• wherein:
• R1 is a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl, phenyl-C1-C3-alkyl- and heteroaryl-C1-C3-alkyl-,
• wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of hydroxy, cyano, halogen, C1-C6-alkyl-, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, —OP(═O)(OH)2, —C(═O)OH, and —C(═O)NH2;
• R2 is a group selected from
• R3 is a group selected from a fluoro atom, chloro atom, bromo atom, cyano, —SF5, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R4 is a group selected from a hydrogen atom, fluoro atom, chloro atom, bromo atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R5 is a group selected from a hydrogen atom, cyano, —S(═O)2R10, C1-C6-alkyl-, C3-C6-alkenyl-, C3-C6-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, and heteroaryl,
• wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R6 and R7 are, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, bromo atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R8 is a group selected from
• a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, and heteroaryl,
• wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• b) a phenyl-C1-C3-alkyl- group, the phenyl group of which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, and C1-C3-alkoxy-;
• c) a heteroaryl-C1-C3-alkyl- group, the heteroaryl group of which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, and C1-C3-alkoxy-;
• d) a C3-C6-cycloalkyl-C1-C3-alkyl- group, the C3-C6-cycloalkyl group of which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• and
• e) a heterocyclyl-C1-C3-alkyl- group, the heterocyclyl group of which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R9a and R9b are, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, bromo atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• and
• R10 is a group selected from C1-C6-alkyl-, halo-C1-C3-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl and heteroaryl,
• wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-,
• or an enantiomer, diastereomer, salt, solvate or salt of solvate thereof.