Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof-I

A compound represented by formula (Ia′), or a pharmaceutically acceptable salt thereof:

• wherein
• n is 1;
• R2 is selected from C1-C4 alkyl, C1-C4 haloalkyl, phenyl, F, or Cl;
• R3 is selected from hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, F, Cl, or CN;
• or
• R2 and R3 together form C4-9 cycloalkyl or C4-9 cycloalkenyl;
• R4 is selected from optionally substituted heteroaryl, optionally substituted heterocyclyl, or optionally substituted aryl;
• and
• R5 is independently selected from hydrogen, or C1-C4 alkyl;
• wherein the optional substituents are each independently selected from halogen, C1-6 alkyl, C1-6alkoxy, C2-6 alkenyl, C2-6 alkynyl, C1-6haloalkyl, C1-6 haloalkoxy, —OH, phenyl, benzyl, phenoxy, benzyloxy, benzoyl, —NH2, —NHC1-4alkyl, —N(C1-4 alkyl)2, —CN, —NO2, mercapto, —P═O(OH)NH2, —S(O)2NH2, —S(O)2NHC1-4 alkyl, —S(O)2N(C1-4 alkyl)2, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, CO2H, —S(O)R′″, and —S(O)2R″″, wherein R′″ is lower alkyl or cycloalkyl and wherein R″″ is lower alkyl, cycloalkyl or OH.