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US 9,790,170 B2Granted
Method for preparing lacosamide
AssigneeSt Pharm Co., Ltd.
InventorsGeun Jho Lim, Sun Ki Chang, Jae Hun Kim, Jong Moon Park
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Abstract
The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.
Claims12
A method for preparing lacosamide of Formula 1:
- wherein Bn represents a benzyl group,
- the method comprising:
- preparing a compound of Formula 3:
- by reacting a compound of Formula 2:
- with a methylating agent in the presence of an inorganic lithium compound and only water as a solvent;
- and
- preparing the lacosamide of Formula 1 by reacting the compound of Formula 3 with benzylamine.
4 more elements
Dependencies are inferred from the claim text.