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AssigneeBASF Pharma (Callanish) Limited
InventorsAdam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
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The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and a second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone.
A composition comprising a PUFA product, ω-6 polyunsaturated fatty acids and ω-3 eicosatetraenoic acid, wherein the PUFA product is EPA present in an amount greater than 96 wt %, wherein the composition comprises an amount of ω-6 polyunsaturated fatty acids up to 0.40 wt %, and wherein the composition comprises an amount of ω-3 eicosatetraenoic acid from 0.05 to 1 wt %.
A composition comprising a PUFA product and at least one of ω-3 polyunsaturated fatty acids and ω-3 polyunsaturated fatty acids, wherein the PUFA product is a mixture of EPA and DHA, wherein (i) the total content of EPA and DHA is 80 wt % or greater, (ii) the content of EPA is from 41 to 60 wt % and the content of DHA is from 16 to 48 wt %, and (iii) the total content of ω-3 polyunsaturated fatty acids is 94 wt % or greater and/or the composition comprises an amount of ω-6 polyunsaturated fatty acids up to 4 wt %;
A composition comprising a PUFA product and at least one of polyaromatic hydrocarbons, dioxins, furans, dibenzeno-para-dioxis, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls, wherein the composition comprises (a) an amount of polyaromatic hydrocarbons in the composition up to 0.89 pg/kg, (b) an amount of dioxins, furans, dibenzeno-para-dioxins and polychlorinated dibenzofurans up to 0.35 pg/g, (c) an amount of polychlorinated biphenyls up to 0.0035 mg/kg, and/or (d) an amount of dioxins, furans, dibenzeno-para-dioxins, polychlorinated dibenzofurans and dioxin-like polychlorinated biphenyls up to 1 pg/g.
A composition comprising a PUFA product and isomeric impurities, wherein the composition comprises an amount of the isomeric impurities up to 1 wt %.
Dependencies are inferred from the claim text.