System and method for in-layer synchronization for fast spot rescanning

A radiation application system comprising:

• a particle accelerator configured to produce a plurality of irradiated particles;
• a gantry configured to receive the plurality of irradiated particles and to rotate around a target subject;
• a treatment nozzle comprised in the gantry, the treatment nozzle configured to emit the plurality of irradiated particles as a directed beam at a target area in the target subject;
• a sensor device configured to monitor a movement of the target area;
• and
• a client computing device comprising:
• a memory device configured to store a target radiation plan comprising a timed sequence for administering a target dosage to the target area using a plurality of applications of the directed beam of irradiated particles;
• a processor configured adjust the target radiation plan to align the plurality of applications of the directed beam of protons with a movement of the target area, and to program a movement of the gantry around the target subject and an emission of the treatment nozzle to apply the directed beam of irradiated particles according to the adjusted target radiation plan.

A non-transitory computer readable medium comprising a plurality of programmed instructions which, when executed by a processor in a computing system, is operable to implement a target radiation plan, the computer readable medium comprising:

• instructions to access a target radiation plan, the target radiation plan comprising a timed sequence for administering a target dosage to a target area using a plurality of applications of a spot-scanning beam of protons;
• instructions to monitor a periodic movement of the target area;
• instructions to generate an adjusted target radiation plan by adjusting the target radiation plan align the plurality of applications of the directed beam of protons with a movement of the target area;
• and
• instructions to apply a directed beam of protons at a plurality of proximate locations comprising the target area according to the adjusted target radiation plan.