System design and method for verifying 3D dosimetric imaging of charged particles in media
AssigneesPurdue Research Foundation, St. Jude Children's Research Hospital
InventorsVadim Moskvin, Keith Michael Stantz
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Abstract
A method of verifying therapeutic proton beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) proton dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam.
Claims20
A non-transitory computer-readable storage device storing computer-executable instructions that when executed by a computer cause the computer to perform a method for verification of accuracy of delivery of a charged particle beam to a tumor in a human body, the method comprising:
- irradiating the tumor with the charged particle beam;
- receiving an ultrasound signal generated due to the irradiation of the tumor by the charged particle beam;
- mapping a three-dimensional source of the ultrasound signal;
- wherein the ultrasound signal is formed at the source in the human body due to thermo-acoustic mechanism of a stress wave generation from energy loss of charged particles associated with the charged particle beam;
- and
- determining a value of falloff of the ultrasound signal corresponding to a distal edge of the charged particle beam associated with a Bragg peak.
A system of performing proton treatment therapy, the system comprising:
- means for developing a radioacoustic image of a proton beam incident on an in vivo target;
- means for locating a distal edge of the proton beam from the radioacoustic image;
- and
- means for performing the proton treatment therapy based upon the located distal edge of the proton beam.
A system for verification of accuracy of delivery of a charged proton beam to a target, the system comprising:
- a dosimetric scanner configured to receive projections from a plurality of projection angles;
- means for reconstructing an ultrasound signal based, at least in part on the projections;
- and
- means for scoring a dose a value of falloff of the ultrasound signal corresponding to a distal edge of the charged particle beam associated with a Bragg peak.
Dependencies are inferred from the claim text.