Device and implantation system for electrical stimulation of biological systems

A method of determining a plurality of stimulation parameters for an electrical stimulation device, wherein said electrical stimulation device comprises at least one electrode in electrical communication with a lower esophageal sphincter (LES) of a patient, a waveform generator coupled to the at least one electrode, and a controller configured to control the waveform generator, the method comprising:

• applying a first of a plurality of stimulation sequences, wherein the first of a plurality of stimulation sequences is defined by a first pulse frequency, a first pulse duration, and a first pulse amplitude and wherein the first of a plurality of stimulation sequences is applied via said at least one electrode in electrical communication with the LES of the patient;
• evaluating a pressure response of the patient's LES;
• terminating the first of the plurality of stimulation sequences when the LES of the patient exhibits a pressure response of at least 20 mm Hg sustained for at least 5 minutes;
• waiting until a pressure of the patient's LES decreases to less than 10 mm Hg or to a baseline pressure, whichever is higher;
• and
• applying a second of the plurality of stimulation sequences, wherein the second of the plurality of stimulation sequences is defined by a second pulse frequency, a second pulse duration, and a second pulse amplitude and wherein the second of a plurality of stimulation sequences is applied via said at least one electrode in electrical communication with the LES of the patient.