Force-controlled applicator for applying a microneedle device to skin

An applicator for applying a microneedle array to a skin surface, the applicator comprising:

• a first portion comprising a microneedle array and defining a first major surface from which the microneedle array protrudes, the first major surface configured to be substantially parallel with the skin surface and configured to be positioned toward the skin surface;
• and
• a second portion coupled to the first portion via a connector that directly contacts both the first portion and the second portion, the connector configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when an application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first major surface of the first portion that meets or exceeds a threshold application force, the second portion defining a second major surface, the second major surface configured to be positioned toward the skin surface;
• wherein at least a portion of the microneedle array extends beyond the first major surface and the second major surface when the connector is in the first state,
• wherein the applicator is configured to be pressed as a whole in a direction substantially perpendicular to the first major surface to press the microneedle array into the skin surface until the threshold application force is reached and the connector is changed to its second state such that after the threshold application force is reached or exceeded continued pressure on the second portion in the direction of the skin will not cause continued pressure on the microneedle array, wherein
• the second portion is movable relative to the first portion between
• (i) a first position in which the connector is in its first state, and the applicator is configured to be applied to the skin surface, and
• (ii) a second position in which the connector is in its second state, and the microneedles are inserted into the skin;
• and wherein
• the second portion is movable relative to the first portion by the connector being changed from its first state to its second state.