Catheter shaft with enhanced platelet anti-adhesion surfaces

A method of manufacturing a catheter comprising:

• extruding a catheter shaft from a composition comprising a polyurethane and additives, the additives comprising a fluoropolymer comprising terminal polyfluoro-oligomeric groups;
• wherein the additives comprise 1.5-2.5 percent by weight of the composition,
• wherein the fluoropolymer comprises a trimer in an amount greater than 0 and less than 5.0 percent by weight of the fluoropolymer, wherein the trimer is formed by a reaction of one equivalent of a diisocyanate with two equivalents of a perfluorinated alcohol to form a low molecular weight fluoropolymer component containing no soft segment, and
• wherein the polyurethane has a shore durometer of between 60A and 95A.

A method of reducing clinical complications caused by the accumulation of thrombus on the surfaces of an indwelling catheter, the method comprising:

• advancing a catheter to a target site within the vasculature, the catheter comprising:
• a catheter shaft, wherein the catheter shaft comprises:
• a polymeric material comprising polyurethane and additives, the additives comprising a fluoropolymer comprising terminal polyfluoro-oligomeric groups;
• wherein the additives comprise 1.5-2.5 percent by weight of the catheter shaft,
• wherein the fluoropolymer comprises a trimer in an amount greater than 0 and less than 5.0 percent by weight of the fluoropolymer, wherein the trimer is formed by a reaction of one equivalent of a diisocyanate with two equivalents of a perfluorinated alcohol to form a low molecular weight fluoropolymer component containing no soft segment, and
• wherein the polyurethane has a shore durometer of between 60A and 95A.