Compositions and methods for cardiac therapy
AssigneeThe Regents of the University of California
InventorsKaren Christman, Jennifer Singelyn, Jessica Dequach
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
Claims18
A composition comprising digested, decellularized extracellular matrix derived from cardiac tissue, the extracellular matrix having a pore size of about 30 to 40 microns, wherein the composition is injectable through a catheter with an inner diameter of 25G or smaller, and wherein the extracellular matrix comprises glycosaminoglycan in a concentration of between about 60 to 120 μg mL of the extracellular matrix.
A tissue culture device comprising:
- a composition comprising digested, decellularized extracellular matrix derived from cardiac tissue, the extracellular matrix having a pore size of about 30 to 40 microns;
- and a substrate, wherein the tissue culture device is used for in vitro tissue culture;
- and wherein the extracellular matrix comprises from about 10 to about 20 ug of glycosaminoglycans per mg of the extracellular matrix.
Dependencies are inferred from the claim text.