Biocompatible phase invertible proteinaceous compositions and methods for making and using the same
AssigneeMallinckrodt Pharma IP Trading D.A.C.
InventorsRonald Dieck, Ian J. Handley, Neil Winterbottom, Joanna Wong
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Abstract
Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.
Claims9
A method of producing a phase invertible composition, said method comprising:
- combining:
- (a) a liquid proteinaceous substrate;
- and
- (b) a liquid crosslinking composition comprising a macromolecular crosslinking agent which comprises a reaction product of an excess of a liquid aldehyde crosslinking agent and a glycosaminoglycan, wherein the liquid crosslinking composition has been formed prior to combining with the liquid proteinaceous substrate to produce said phase invertible composition;
- wherein said phase invertible composition is exposed to radiation.
A method of producing a phase invertible composition, said method comprising:
- combining:
- (a) a liquid proteinaceous substrate;
- and
- (b) a liquid crosslinking composition comprising a macromolecular crosslinking agent which comprises a reaction product of an excess of a liquid aldehyde crosslinking agent and hyaluronic acid, wherein the liquid crosslinking composition has been formed prior to combining with the liquid proteinaceous substrate to produce said phase invertible composition;
- wherein said phase invertible composition is exposed to radiation.
Dependencies are inferred from the claim text.