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US 9,789,212 B2Granted
Methods for diagnosing and monitoring eosinophilic esophagitis
AssigneeUniversity of Utah Research Foundation
InventorsLeonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment.
Claims15
A method of producing a medical image of an esophagus in a subject, said method comprising:
- administering to a subject radiolabeled heparin wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the subject's esophagus, wherein said binding generates a radiolabeled heparin eosinophil granule protein complex, wherein the eosinophil granule protein is major basic protein 1 (MBP-1), major basic protein 2 (MBP-2), eosinophil derived neurotoxin (EDN), eosinophil cationic protein (ECP), or eosinophil peroxidase (EPO), and
- detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the subject's esophagus,
- whereby detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the esophagus produces a medical image of the esophagus in the subject.
A method of diagnosing eosinophilic esophagitis in a subject, the method comprising:
- administering to a subject radiolabeled heparin wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the subject's esophagus, wherein said binding generates a radiolabeled heparin eosinophil granule protein complex, wherein the eosinophil granule protein is major basic protein 1 (MBP-1), major basic protein 2 (MBP-2), eosinophil derived neurotoxin (EDN), eosinophil cationic protein (ECP), or eosinophil peroxidase (EPO), and
- detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the esophagus,
- whereby detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the esophagus diagnoses eosinophilic esophagitis in the subject.
A method of detecting eosinophil degranulation in a subject, the method comprising:
- administering to a subject radiolabeled heparin wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the subject's esophagus, wherein said binding generates a radiolabeled heparin eosinophil granule protein complex, wherein the eosinophil granule protein is major basic protein 1 (MBP-1), major basic protein 2 (MBP-2), eosinophil derived neurotoxin (EDN), eosinophil cationic protein (ECP), or eosinophil peroxidase (EPO), and
- detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the subject's esophagus,
- whereby detecting the radiolabeled heparin eosinophil granule protein complex in the mucosal tissue of the esophagus detects eosinophil degranulation in the subject.
Dependencies are inferred from the claim text.