Methods and compositions for positron emission tomography myocardial perfusion imaging
AssigneeUniversity of Southern California
InventorsPeter S. Conti, Shuanglong Liu, Zibo Li
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Abstract
This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.
Claims6
A multi-unit molecule useful as an imaging tracer, comprising:
- one or more cationic units;
- one or more hexaaza sacophogine cage (sar) multifunctional chelator units;
- and
- one or more hydrophobic units,
- wherein said one or more cationic units, one or more sar multifunctional chelator units and one or more hydrophobic units may be linked directly to each other or via a linker arranged in any sequential order in a linear linkage,
- wherein said one or more cationic units is selected from the group consisting of TPP, —P+R1R2R3 and —N+R1R2R3, wherein R1, R2, and R3 are each independently selected from an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted alkyl, an optionally substituted cycloalky, or an optionally substituted heteroaryl, wherein said one or more sar multifunctional chelator units is one selected from the group consisting of BaBaSar, AnAnSar, BaAnSar, BaMalSar, and MalMalSar,
- wherein said one or more hydrophobic units is selected from the group consisting of:
Dependencies are inferred from the claim text.