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US 9,789,210 B1Granted
Methods for making ultrasound contrast agents
AssigneeLantheus Medical Imaging, Inc.
InventorsSimon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Life of this patent
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Abstract
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Claims9
A method of ultrasound contrast imaging a subject comprising
- (a) activating a phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres, wherein the phospholipid suspension comprises a phospholipid solution having DPPA, DPPC and MPEG5000-DPPE, in a mole % ratio of 10 to 82 to 8 (10:82:8), in propylene glycol, the MPEG5000-DPPE selected as having a calcium concentration of less than 115 parts per million (ppm), and the phospholipid solution having a calcium concentration of less than 0.7 ppm,
- (b) administering the lipid-encapsulated gas microspheres to a subject, and
- (c) obtaining an ultrasound image of the subject.
A method of ultrasound contrast imaging a subject comprising
- (a) activating a phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres, wherein the phospholipid suspension comprises a phospholipid solution made under a methanol and toluene free condition and a methyl t-butyl ether free condition and having DPPA, DPPC and MPEG5000-DPPE, in a mole % ratio of 10 to 82 to 8 (10:82:8), in propylene glycol, the MPEG5000-DPPE having a calcium concentration of less than 115 parts per million (ppm), and the phospholipid solution having a calcium concentration of less than 0.7 ppm,
- (b) administering the lipid-encapsulated gas microspheres to a subject, and
- (c) obtaining an ultrasound image of the subject.
Dependencies are inferred from the claim text.