Method of fabricating [F-18]FEONM

A method of fabricating FEONM, 2-(1-{6-[(2-2′-[F-18]Fluoroethoxyethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([F-18]FEONM), comprising steps of:

• (a) washing out fluoride ions (F-18), being adhered on an ion exchange resin, with potassium carbonate/2.2.2 cryptand in acetonitrile-water into a reaction vessel;
• (b) heating said reaction vessel to be heated to a temperature of 75-115 celsius degrees (° C.), cooling said temperature down to 40-60° C. and excluding water after processing a first azeotropic distillation with helium;
• (c) adding acetonitrile to said reaction vessel to be heated to a temperature of 75-115° C., cooling said temperature down to 40-60° C. and excluding water after processing a second azeotropic distillation with helium;
• (d) adding a precursor to said reaction vessel to be heated to a temperature of 90-130° C. to process a fluorination reaction for 10-20 minutes to obtain a reaction mixture;
• and
• (e) after said fluorination reaction, cooling down a temperature of said reaction mixture to 40-60° C. followed by flowing said reaction mixture through a solid phase extraction column with waste drained into a waste tank and washing out a final product of [F-18]FEONM, being adhered on said column, with ethanol to be collected in a collection vial.