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US 9,789,205 B2Granted
Compositions and methods for gene therapy
AssigneeBoard of Regents of the University of Nebraska
InventorsAlexander Kabanov, Elena Batrakova, Vivek Mahajan, Matthew J. Haney
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Abstract
Compositions and methods for transferring a nucleic acid to a target cell using an immune system cell are provided.
Claims11
A method of transferring a nucleic acid to a target cell, comprising:
- first transiently transfecting an immune system cell with the nucleic acid, and
- then contacting the target cell with the immune system cell that has been transiently transfected with the nucleic acid,
- wherein the nucleic acid is transferred to the target cell,
- wherein the immune system cell is a macrophage or monocyte and the target cell is a neuron, muscle cell, or fibroblast, and
- wherein the nucleic acid is RNA.
2 more elements
A method of transferring a nucleic acid to a target cancer cell, comprising:
- first transiently transfecting an immune system cell with the nucleic acid, and
- then contacting the target cancer cell with the immune system cell that has been transiently transfected with the nucleic acid,
- wherein the nucleic acid is transferred to the target cell, and
- wherein the immune system cell is a macrophage or monocyte.
1 more element
A method of transferring a nucleic acid to a target cell, comprising:
- first transiently transfecting an immune system cell with the nucleic acid in vitro or ex vivo, and then contacting the target cell with the immune system cell that has been transiently transfected with the nucleic acid,
- wherein the nucleic acid is transferred to the target cell,
- wherein the immune system cell is a macrophage or monocyte, and
- wherein the nucleic acid is RNA.
1 more element
Dependencies are inferred from the claim text.