EMD formulation comprising PGA
AssigneeStraumann Holding AG
InventorsLaszlo Garamszegi, Andri Vital
Life of this patent
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Abstract
Enamel Matrix Derivative (EMD) proteins and enamel matrix proteins are widely used in clinical dentistry because of their ability to promote regeneration of soft and hard tissues and to reduce inflammation and infections. The present invention relates to the surprising finding that a pharmaceutical, dental and/or cosmetic formulation, which comprises purified Enamel Matrix Derivative (EMD) proteins and/or enamel matrix proteins and sterilized Propylene Glycol Alginate (PGA), wherein the sterilized PGA is obtained from non-sterilized PGA having a weight average molecular weight (Mwo) of between 250-500 kDa, is more stable over time, especially, the pH is more stable over time.
Claims23
A pharmaceutical, dental and/or cosmetic formulation comprising enamel matrix proteins and/or enamel matrix derivative (EMD) proteins and a sterilized propylene glycol alginate, wherein said formulation comprises no more than 6 weight/volume % (w/v %) sterilized propylene glycol alginate (PGA), wherein the weight average molecular weight (Mw) of the PGA prior to sterilization is at least 250 kDa, and wherein said sterilized PGA has a weight average molecular weight (Mw) above 130 kDa.
A pharmaceutical, dental and/or cosmetic formulation, comprising enamel matrix proteins and/or enamel matrix derivative (EMD) proteins and sterilized propylene glycol alginate (PGA) with a weight average molecular weight above 130 kDa, wherein said formulation is produced by a process comprising the following steps:
- a. isolating enamel matrix proteins and/or enamel matrix derivative (EMD) proteins from a developing mammal's teeth,
- b. e-beam sterilizing non-sterilized PGA with an initial weight average molecular weight (Mwo) in the range of 250 to 500 kDa with a dose in the range of 25 to 30 kGy, and
- c. mixing the product obtained from a. and the product obtained from b.
Dependencies are inferred from the claim text.