Back to results
US 9,789,186 B2Granted
Reactive oxidative species generating materials and methods of use
AssigneeW. L. Gore & Associates, Inc.
InventorsTiffany J. Brown, Adam S. Lafleur, Kenneth Mazich, Jeffrey C. Towler, Ji Zhang
Life of this patent
Estimating the term…
Abstract
Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.
Claims28
A method of stimulating blood vessel formation comprising:
- applying at least one semi-crystalline, hydrolytically degradable polymeric material comprising stabilized free radicals to a treatment site, wherein the polymeric material has been subjected to ionizing radiation at a dose that exceeds that required for sterilization but is less than that required to substantially degrade the polymeric material,
- wherein the at least one semi-crystalline, hydrolytically degradable polymeric material comprises a first polymeric material and a second polymeric material, and
- wherein the first polymeric material and the second polymeric material have been subjected to different doses of ionizing radiation.
A method of stimulating blood vessel formation comprising:
- applying at least one semi-crystalline, hydrolytically degradable polymeric material comprising stabilized free radicals to a treatment site, wherein the polymeric material has been subjected to ionizing radiation at a dose of less than 50 kGy and is sterilized by non-ionizing radiation methods,
- wherein the at least one semi-crystalline, hydrolytically degradable polymeric material comprises a first polymeric material and a second polymeric material, and
- wherein the first polymeric material and the second polymeric material have been subjected to different doses of ionizing radiation.
Dependencies are inferred from the claim text.