Anti-EGFR antibodies and uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsChristopher Daly, Gavin Thurston, Nicholas J. Papadopoulos
Life of this patent
Estimating the term…
Abstract
The present invention provides antibodies that bind to EGFR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human EGFR with high affinity. In certain embodiments, the antibodies of the present invention are capable of inhibiting the growth of tumor cells expressing high levels of EGFR and/or inducing antibody-dependent cell-mediated cytotoxicity (ADCC) of such cells. The antibodies of the invention are useful for the treatment of various cancers as well as other EGFR-related disorders.
Claims13
A method for inhibiting tumor growth, the method comprising administering to a subject afflicted with a tumor a pharmaceutical composition comprising an antibody or antigen-binding fragment thereof that specifically binds human epidermal growth factor receptor (hEGFR), wherein the antibody or antigen-binding fragment thereof comprises:
- (a) the complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO:130, and (b) the CDRs of a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO:138.
Dependencies are inferred from the claim text.